Thomas Fellmeth

Computational simulations of the conformational changes within Tau protein and its fibrilization

Lector: Jozef Hritz

Institution: Masaryk University, CEITEC MU

Field: Life Sciences

 

About the project

Tau protein fibrilization is a key process in the development of Alzheimer’s disease. The aim of the study is to investigate the influence of different reaction conditions, especially phosphorylations, on the conformational dynamic and the fibrilization mechanism of Tau proteins. Therefore, molecular dynamics simulations on coarse-grained and atomistic level of resolution will be performed. The computational results will then be validated by experimental ones from cryogenic electron microscopy.

 

Why science?

Science has always fascinated me because it is full of new challenges. I like discovering and understanding new phenomena because I am convinced that science has a great impact on our society. Especially in my current PhD project on Alzheimer's disease, I like that my research contributes to the understanding of this neurogenerative disease and thus creates the basis for the development of new medical treatments.

 

What do I like most about Brno

In Brno, I particularly like the architecture of the city centre and its sights. The Cathedral of St. Paul and Peter is beautiful and its tower offers a lovely view of the entire town. In summer, the Brno Dam is a great place to meet up with friends and enjoy the Sun or take a boat trip to Veveří Castle. Furthermore, there are many cultural events, such as concerts, theatre or folklore events, which I greatly recommend.